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Gene Symbol | IDH2 | ||||||||||
Synonyms | D2HGA2 | ICD-M | IDH | IDH-2 | IDHM | IDP | IDPM | mNADP-IDH | ||||||||||
Gene Description | IDH2, isocitrate dehydrogenase (NADP(+)) 2, is an enzyme that catalyzes the conversion of isocitrate to alpha-ketoglutarate (alpha-KG), and is involved in the tricarboxylic acid cycle (PMID: 28711227, PMID: 28980701). Mutations in IDH2 are associated with aberrant conversion of alpha-KG to 2-HG, which is an oncogenic metabolite, and are recurrent in acute myeloid leukemia and subtypes of glioma (PMID: 27621679, PMID: 19228619, PMID: 23999441). | ||||||||||
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