Gene Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@genomenon.com

Gene Symbol IFIT3
Synonyms CIG-49 | cig41 | GARG-49 | IFI60 | IFIT4 | IRG2 | ISG60 | P60 | RIG-G
Gene Description IFIT3, interferon induced protein with tetratricopeptide repeats 3, is a member of the IRF-inducible gene family that plays a role in the immune defense against RNA viruses and regulation of apoptosis (PMID: 30234477, PMID: 31921891). Overexpression of Ifit3 in pancreatic ductal adenocarcinoma has been associated with decreased cell apoptosis, resistance to chemotherapy, and poor prognosis (PMID: 28210844) however, in hepatocellular carcinoma Ifit3 overexpression shows a better response to interferon-alpha (PMID: 28295457), and in head and neck squamous cell carcinoma (HNSCC) Ifit3 overexpression is associated with poor prognosis (PMID: 31977029).
Additional content available in CKB BOOST