Gene Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@genomenon.com

Gene Symbol IRS1
Synonyms HIRS-1
Gene Description IRS1, insulin receptor substrate 1, encodes an adaptor protein that acts as a substrate for a variety of receptors including the insulin and insulin-like growth factor receptors, thereby mediating insulin signaling and subsequent PI3K signaling, and cytokine receptors, leading to JAK/STAT pathway signaling (PMID: 8384986, PMID: 15157524). Overexpression of IRS1 has been identified in pancreatic cancer (PMID: 8607861), hepatocellular carcinoma (PMID: 16127164), and breast cancer (PMID: 9815941).
Additional content available in CKB BOOST