To all our CKB CORE users, don’t miss the latest new features now available! Register for a free CORE account here and then login for access. Feel free to contact us at ckbsupport@genomenon.com if you have any questions!

JAK1 - Gene Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@genomenon.com

Gene Symbol JAK1
Synonyms AIIDE | JAK1A | JAK1B | JTK3
Gene Description JAK1, Janus kinase 1, is a non-receptor protein tyrosine kinase involved in the interferon-alpha/beta/gamma pathway and is a member of the JAK/STAT signaling pathway (PMID: 15575979) and plays a role in the immune response (PMID: 31892268). JAK1 gain of function mutations have been identified in T-cell neoplasms (PMID: 30079384) and loss of function mutations are associated with high mutational burden and microsatellite instability (PMID: 29121062).
NCBI Gene ID Chromosome Map Location Canonical Transcript Gene Role
3716 1 1p31.3 NM_002227 Both: Oncogene and Tumor suppressor (PMID: 30606230)

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Spaces will be interpreted literally in the search. Use the percentage character '%' as a wildcard to search for multiple values
  • When searching for values delimited by '%', searches are ordered by their appearance in the text. (i.e. 'A%C' will likely return different results than 'C%A')
  • Precede text with a caret '^' to indicate search should "start with" the text
  • Follow text with a dollar sign '$' to indicate search should "end with" the preceding text

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Variant Impact Protein Effect Variant Description Associated With Drug Resistance
Variant Impact Protein Effect Variant Description Associated With Drug Resistance
Molecular Profile Protein Effect Treatment Approaches
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries