KLRD1 - Gene Detail
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| Gene Symbol | KLRD1 | ||||||||||||
| Synonyms | CD94 | ||||||||||||
| Gene Description | KLRD1, killer cell lectin like receptor D1, also referred to as CD94, heterodimerizes with NKG2 proteins including NKG2A, -2C, and -2E (PMID: 21439856) to form peptide-selective NK-cell receptors that play a role in immune response (PMID: 24082146, PMID: 21439856), and the KLRD1 (CD94)-NKG2A inhibitory receptor may be involved in tumor cell immune evasion (PMID: 15805295, PMID: 36706761). KLRD1 deletion and mutations have been identified in acute lymphoblastic leukemia (PMID: 35652109) and differential expression of KLRD1 has been observed in various tumor types, including head and neck squamous cell carcinoma (PMID: 39781341). | ||||||||||||
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