Gene Detail
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| Gene Symbol | L1CAM | ||||||||||
| Synonyms | CAML1 | CD171 | HSAS | HSAS1 | HYCX | MASA | MIC5 | N-CAM-L1 | N-CAML1 | NCAM-L1 | S10 | SPG1 | ||||||||||
| Gene Description | L1CAM, L1 cell adhesion molecule, is a member of the immunoglobulin superfamily (IgSF) of molecules that plays a role in cell adhesion and cytoskeleton formation through interactions with other IgSF family members (PMID: 9396761, PMID: 26909348) and interacts with tyrosine kinase receptors to modulate downstream signaling (PMID: 22815787). L1CAM overexpression is associated with poor prognosis in several tumor types (PMID: 27833079), including endometrial cancer (PMID: 23781004, PMID: 25126672, PMID: 36399812), and gastric cancer (PMID: 23806079, PMID: 24422715). | ||||||||||
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