Gene Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@genomenon.com

Gene Symbol L1CAM
Synonyms CAML1 | CD171 | HSAS | HSAS1 | HYCX | MASA | MIC5 | N-CAM-L1 | N-CAML1 | NCAM-L1 | S10 | SPG1
Gene Description L1CAM, L1 cell adhesion molecule, is a member of the immunoglobulin superfamily (IgSF) of molecules that plays a role in cell adhesion and cytoskeleton formation through interactions with other IgSF family members (PMID: 9396761, PMID: 26909348) and interacts with tyrosine kinase receptors to modulate downstream signaling (PMID: 22815787). L1CAM overexpression is associated with poor prognosis in several tumor types (PMID: 27833079), including endometrial cancer (PMID: 23781004, PMID: 25126672, PMID: 36399812), and gastric cancer (PMID: 23806079, PMID: 24422715).
Additional content available in CKB BOOST