MYO18A: Gene Detail - Cancer Knowledgebase (CKB)

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Gene Symbol

MYO18A

Synonyms

MAJN | MYSPDZ | SP-R210 | SPR210 | TIAF1

Gene Description

MYO18A, myosin XVIIIA, encodes a myosin protein that interacts with LURAP1 (PMID: 28942352), thereby playing a role in cell migration and protrusion, and binds to GOLPH3, which allows for Golgi trafficking and morphology (PMID: 27824130). MYO18A fusions have been identified in myeloproliferative disorders (PMID: 15800673, PMID: 19006078, PMID: 30559310, PMID: 28261327), and MYO18A overexpression has been observed in metastatic prostate cancer cells (PMID: 26670045).

NCBI Gene ID	Chromosome	Map Location	Canonical Transcript	Gene Role
399687	17	17q11.2	NM_078471	Unknown

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Gene Variants 7
Category Variants 2
Molecular Profiles 7
Evidence 2
Clinical Trials 0

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MYO18A - Gene Detail

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