MDM2: Gene Detail - Cancer Knowledgebase (CKB)

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Gene Symbol

MDM2

Synonyms

ACTFS | hdm2 | HDMX | LSKB

Gene Description

MDM2, MDM2 proto-oncogene, is an E3 ubiquitin protein ligase that mediates Tp53 degradation and therefore, regulates apoptosis and cell-cycle (PMID: 27993876). Amplification and/or overexpression of MDM2 has been identified in several cancer types (PMID: 23303139, PMID: 31440117) and amplification is common in liposarcoma (PMID: 30237864) and has been observed with Mdm2 overexpression in anaplastic lymphoma kinase (ALK)-negative inflammatory myofibroblastic tumors (PMID: 32195970).

NCBI Gene ID	Chromosome	Map Location	Canonical Transcript	Gene Role
4193	12	12q15	NM_001367990	Oncogene (PMID: 30606230)

Additional content available in

CKB BOOST

Gene Variants 53
Category Variants 3
Molecular Profiles 91
Evidence 86
Clinical Trials 12

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Genes

(50 Genes)

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Gene Variants

Therapies

Limited

Global Drug Approvals

Drug Classes

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Clinical Trials

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Efficacy Evidence

Variant Tier Coding
(AMP/CAP/ASCO)

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The public access version, CKB CORE™, encompasses 50 cancer-related genes, and every quarter, a select group of genes are exchanged, focusing on a specific theme. Users can search CKB CORE™ via gene and gene variants. The web-based, subscription version, CKB BOOST™, includes more than 2000 cancer-related genes and is designed to interrogate the knowledgebase for specific data attributes while enabling a robust browse-like feature when the desired content is unknown.

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MDM2 - Gene Detail

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