Starting April 21, you’ll be asked to log in or sign up for a free account after viewing 10 content pages each month.
Don’t worry—creating an account is quick and easy, and it comes with added benefits! Once logged in, you’ll not only continue accessing the content you already enjoy, but you’ll also unlock exclusive features like interactive donut plots for variant protein effects and variant impacts across the gene.
Stay tuned for these updates, and thank you for being part of our community!
Missing content? – Request curation!
Request curation for specific Genes, Variants, or PubMed publications.
Have questions, comments, or suggestions? - Let us know!
Email us at : ckbsupport@genomenon.com
Gene Symbol | MAP3K4 | ||||||||||
Synonyms | MAPKKK4 | MEKK 4 | MEKK4 | MTK1 | PRO0412 | ||||||||||
Gene Description | MAP3K4, mitogen-activated protein kinase kinase kinase 4, encodes a member of the MAPK superfamily of protein kinases, which can be activated by cellular stress, leading to activation of the MAP2K-MAPK signaling pathway, and has been demonstrated to play a role in development, including mammalian sex determination (PMID: 31346208, PMID: 24928207, PMID: 17348032). MAP3K4 mutations have been identified in triple-receptor negative breast cancer (PMID: 25079324) and overexpression of MAP3K4 has been identified in small cell lung cancer (PMID: 16705311). | ||||||||||
|