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Gene Symbol MITF
Synonyms bHLHe32 | CMM8 | COMMAD | MI | MITF-A | WS2 | WS2A
Gene Description MITF, melanocyte inducing transcription factor, encodes for a transcription factor that plays a key role in the development, differentiation, and survival of melanocytes, and transcription of the HIF1A gene (PMID: 23207919, PMID: 22012259). MITF amplification has been observed in melanoma while MITF mutations, in particular germline mutations, may increase the risk for melanoma and renal cancer (PMID: 25433395, PMID: 22012259, PMID: 32249949).
NCBI Gene ID Chromosome Map Location Canonical Transcript Gene Role
4286 3 3p13 NM_001354604 Oncogene (PMID: 30606230)
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