MME: Gene Detail - Cancer Knowledgebase (CKB)

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Gene Symbol

MME

Synonyms

CALLA | CD10 | CMT2T | NEP | SCA43 | SFE

Gene Description

MME, membrane metalloendopeptidase, encodes a membrane glycoprotein found on various cell types and plays a role in the activation of neutrophils (PMID: 21425402), normal B-cell development and differentiation (PMID: 27965895), and mammary gland development (PMID: 21425402). MME expression has been associated with multiple lymphoma subtypes, including diffuse large B-cell lymphoma (PMID: 11293907) and angioimmunoblastic T-cell lymphoma (PMID: 11781247) and increased expression of MME has been identified in several tumor types, including breast cancer, prostate cancer, and melanoma (PMID: 21425402).

NCBI Gene ID	Chromosome	Map Location	Canonical Transcript	Gene Role
4311	3	3q25.2	NM_007289	Unknown

Additional content available in

CKB BOOST

Gene Variants 1
Category Variants 0
Molecular Profiles 1
Evidence 0
Clinical Trials 1

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Genes

(50 Genes)

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Gene Variants

Therapies

Limited

Global Drug Approvals

Drug Classes

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Clinical Trials

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Efficacy Evidence

Variant Tier Coding
(AMP/CAP/ASCO)

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The public access version, CKB CORE™, encompasses 50 cancer-related genes, and every quarter, a select group of genes are exchanged, focusing on a specific theme. Users can search CKB CORE™ via gene and gene variants. The web-based, subscription version, CKB BOOST™, includes more than 2000 cancer-related genes and is designed to interrogate the knowledgebase for specific data attributes while enabling a robust browse-like feature when the desired content is unknown.

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MME - Gene Detail

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