Gene Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@genomenon.com

Gene Symbol MN1
Synonyms CEBALID | dJ353E16.2 | MGCR | MGCR1 | MGCR1-PEN
Gene Description MN1, MN1 proto-oncogene, transcriptional regulator, encodes a transcriptional co-factor that interacts with Rac3 and p300 to regulate gene expression of RARA/RXR targets (PMID: 12569362), and plays a role in craniofacial development (PMID: 15870292, PMID: 31834374), hematopoiesis (PMID: 18632758), and osteoclast proliferation (PMID: 19386590). Increased MN1 expression has been observed in acute myeloid leukemia (PMID: 27983532) and colorectal cancer (PMID: 31133374), and MN1 fusions with BEND1, ETV6, and STAT3 have been identified in myeloid leukemia and astroblastoma (PMID: 11094079, PMID: 29348602, PMID: 31902945).
NCBI Gene ID Chromosome Map Location Canonical Transcript Gene Role
4330 22 22q12.1 NM_002430 oncogene (PMID: 30606230)
Additional content available in CKB BOOST