Gene Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@genomenon.com

Gene Symbol MPL
Synonyms C-MPL | CD110 | MPLV | THCYT2 | THPOR | TPOR
Gene Description MPL, MPL proto-oncogene, thrombopoietin receptor, binds the cytokine, thrombopoietin, to induce signaling of JAK2 and TYK2 to activate several signal transduction pathways to control blood cell development (PMID: 16834459, PMID: 28408900). MPL mutations are often found in myeloproliferative neoplasms (PMID: 27727468, PMID: 31858134, PMID: 31750750).
NCBI Gene ID Chromosome Map Location Canonical Transcript Gene Role
4352 1 1p34.2 NM_005373 Oncogene (PMID: 30606230)
Additional content available in CKB BOOST