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MSH3 - Gene Detail

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Gene Symbol MSH3
Synonyms DUP | FAP4 | MRP1
Gene Description MSH3, mutS homolog 3, encodes for one of the DNA mismatch repair proteins, which forms a stable heterodimer with MSH2 in order to recognize and repair mismatched DNA (PMID: 8942985), and may play a role in inflammation (PMID: 32284349). Somatic MSH3 mutations have been identified in colon, lung, and breast cancers, and oral squamous cell carcinoma while MSH3 polymorphisms, which may be associated with increased risk, have been observed in ovarian and prostate cancers, and non-small cell lung carcinoma (PMID: 25966119, PMID: 31953835).
NCBI Gene ID Chromosome Map Location Canonical Transcript Gene Role
4437 5 5q14.1 NM_002439 Unknown

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Variant Impact Protein Effect Variant Description Associated With Drug Resistance
Variant Impact Protein Effect Variant Description Associated With Drug Resistance
Molecular Profile Protein Effect Treatment Approaches
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries