MST1R - Gene Detail

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Gene Symbol MST1R
Synonyms CD136 | CDw136 | NPCA3 | p185-Ron | PTK8 | RON | SEA
Gene Description MST1R, macrophage stimulating 1 receptor, encodes the receptor tyrosine kinase RON, which acts as a receptor for macrophage-stimulating protein and is involved in cell migration and differentiation (PMID: 21543897, PMID: 23792360). Alterations in MST1R have been associated with several tumor types (PMID: 23792360) and overexpression of Mst1r has been associated with pancreatic cancer progression (PMID: 30967626).
NCBI Gene ID Chromosome Map Location Canonical Transcript MANE Select Gene Role
4486 3 3p21.31 NM_002447 Y Unknown

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Variant Impact Protein Effect Variant Description Associated With Drug Resistance
Variant Impact Protein Effect Variant Description Associated With Drug Resistance
Molecular Profile Protein Effect Treatment Approaches
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries