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Gene Symbol ZFHX3
Synonyms ATBF1 | ATBT | ATFB8 | C16orf47 | SCA4 | ZFH-3 | ZNF927
Gene Description ZFHX3, zinc finger homeobox 3, encodes a transcription factor that functions as a tumor suppressor by transactivating CDKN1A and repressing AFP (PMID: 29126922, PMID: 20599712). ZFHX3 mutations and loss of heterozygosity have been identified in gastric (PMID: 17671116), prostate (PMID: 15750593), and endometrial cancer (PMID: 26330387).
NCBI Gene ID Chromosome Map Location Canonical Transcript Gene Role
463 16 16q22.2-q22.3 NM_006885 Tumor suppressor (PMID: 30606230)
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