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Gene Symbol NBN
Synonyms AT-V1 | AT-V2 | ATV | hNbs1 | NBS | NBS1 | P95
Gene Description NBN, nibrin, functions as part of the MRN complex, which plays a role in DNA double-strand break repair (PMID: 24396275). Mutations in NBN are associated with increased susceptibility to cancer (PMID: 24396275, PMID: 15279809, PMID: 31278556) and amplification has been observed in ovarian cancer (PMID: 32226530).
NCBI Gene ID Chromosome Map Location Canonical Transcript Gene Role
4683 8 8q21.3 NM_002485 Tumor suppressor (PMID: 30606230)
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