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Gene Symbol | ATM | ||||||||||
Synonyms | AT1 | ATA | ATC | ATD | ATDC | ATE | TEL1 | TELO1 | ||||||||||
Gene Description | ATM, ATM serine/threonine kinase, is a member of the serine-threonine kinase family and coordinates cellular responses to DNA damage through activation of distinct DNA repair and signaling pathways (PMID: 22079189). ATM germline mutations are associated with ataxia telangiectasia (PMID: 27283171) and ATM somatic mutations are commonly observed in endometrial, colon, pancreatic, breast cancers (PMID: 27283171, PMID: 27413114) and urothelial cancer (PMID: 29682192). | ||||||||||
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Variant | Impact | Protein Effect | Variant Description | Associated With Drug Resistance |
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Variant | Impact | Protein Effect | Variant Description | Associated With Drug Resistance |
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Molecular Profile | Protein Effect | Treatment Approaches |
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Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
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Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
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