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NF1 - Gene Detail

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Gene Symbol NF1
Synonyms NFNS | VRNF | WSS
Gene Description NF1, neurofibromin, is a tumor suppressor (PMID: 30562755) which functions as a Ras GTPase-activating protein to regulate cell proliferation and prevent malignant transformation (PMID: 19380279, PMID: 35066574). NF1 germline mutations are common in neurofibromatosis type I (PMID: 30562755) and somatic mutations have been identified in a variety of human cancers (PMID: 28637487).
NCBI Gene ID Chromosome Map Location Canonical Transcript Gene Role
4763 17 17q11.2 NM_001042492 Tumor suppressor (PMID: 30606230)
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