NFKBIA - Gene Detail
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| Gene Symbol | NFKBIA | ||||||||||||
| Synonyms | EDAID2 | IKBA | MAD-3 | NFKBI | ||||||||||||
| Gene Description | NFKBIA, NFKB inhibitor alpha, encodes IKappa B alpha, a member of the nuclear factor kappa B inhibitor family, which is responsible for inactivation of NF-kappa B via inhibition of nuclear localization signals (PMID: 24578542). Inactivating mutations and/or deletion of NFKBIA have been observed in lymphoma (PMID: 19507254), glioblastoma (PMID: 21774728), and nasopharyngeal carcinoma (PMID: 28098136), and NFKBIA variants may confer susceptibility risk to colorectal cancer (PMID: 29564065) and gastric cancer (PMID: 28670959). | ||||||||||||
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