NOTCH3 - Gene Detail
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| Gene Symbol | NOTCH3 | ||||||||||||
| Synonyms | CADASIL | CADASIL1 | CARASIL1 | CASIL | FPLD1 | IMF2 | LMNS | ||||||||||||
| Gene Description | NOTCH3, notch receptor 3, is one of four Notch transmembrane receptors, that bind Delta or Jagged ligands (PMID: 30289388), and plays a role in cell fate regulation, proliferation, and survival (PMID: 30030828). NOTCH3 amplification has been implicated in the development of ovarian high-grade serous carcinoma (PMID: 20001801, PMID: 30723507) and myofibroma (PMID: 31566039) and NOTCH3 overexpression has been implicated in breast cancer metastasis (PMID: 30180881). | ||||||||||||
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