NPM1: Gene Detail - Cancer Knowledgebase (CKB)

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Gene Symbol

NPM1

Synonyms

B23 | NPM

Gene Description

NPM1, nucleophosmin, is a phosphoprotein that shuttles between the nucleus and cytoplasm, and is involved in several cellular processes including ribosomal processing and export, chromatin remodeling, DNA replication and repair, and cell cycle control (PMID: 29157973, PMID: 23436734). NPM1 is frequently mutated in acute myeloid leukemia (PMID: 29157973, PMID: 23436734, PMID: 30122998, PMID: 29785446, PMID: 32203582, PMID: 32609823) and overexpression is implicated with poor prognosis in hematological and solid tumors (PMID: 32071709).

NCBI Gene ID	Chromosome	Map Location	Canonical Transcript	Gene Role
4869	5	5q35.1	NM_002520	Oncogene (PMID: 30606230)

Additional content available in

CKB BOOST

Gene Variants 40
Category Variants 9
Molecular Profiles 91
Evidence 284
Clinical Trials 40

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Gene Variants

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Variant Tier Coding
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The public access version, CKB CORE™, encompasses 50 cancer-related genes, and every quarter, a select group of genes are exchanged, focusing on a specific theme. Users can search CKB CORE™ via gene and gene variants. The web-based, subscription version, CKB BOOST™, includes more than 2000 cancer-related genes and is designed to interrogate the knowledgebase for specific data attributes while enabling a robust browse-like feature when the desired content is unknown.

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NPM1 - Gene Detail

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