Gene Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@genomenon.com

Gene Symbol NTRK1
Synonyms MTC | p140-TrkA | TRK | Trk-A | TRK1 | TRKA
Gene Description NTRK1, neurotrophic receptor tyrosine kinase 1, is a receptor tyrosine kinase involved in maturation and development of the nervous system through MAPK/ERK and AKT/PKB signaling pathways (PMID: 30542115). Fusions involving NTRK1, with multiple gene partners, and producing constitutively active Ntrk1 kinase activity have been demonstrated to be oncogenic in a variety of tumor types (PMID: 25054037), including pediatric cancers (PMID: 31965543) and other solid tumors (PMID: 31145161, PMID: 32127185, PMID: 32133433), while NTRK1 missense mutations are often associated with resistance to TRK inhibition (PMID: 31406350).
NCBI Gene ID Chromosome Map Location Canonical Transcript Gene Role
4914 1 1q23.1 NM_002529 Both: Oncogene and Tumor suppressor (PMID: 30606230)
Additional content available in CKB BOOST