NTRK2 - Gene Detail

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Gene Symbol NTRK2
Synonyms DEE58 | EIEE58 | GP145-TrkB | OBHD | trk-B | TRKB
Gene Description NTRK2, neurotrophic receptor tyrosine kinase 2, is membrane receptor tyrosine kinase that binds neurotrophins, initiating signaling cascades that lead to cell growth and differentiation (PMID: 17008023). Inappropriately regulated NTRK2 may be involved in initiation and metastasis of some cancers (PMID: 17008023) and NTRK2 fusions, with multiple gene partners, have been commonly observed in solid tumors (PMID: 32319699), including glioma (PMID: 28512244, PMID: 24705251), while NTRK2 missense mutations may confer resistance to TRK inhibition (PMID: 21242122).
NCBI Gene ID Chromosome Map Location Canonical Transcript MANE Select Gene Role
4915 9 9q21.33 NM_001018064 N Unknown

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Variant Impact Protein Effect Variant Description Associated With Drug Resistance
Variant Impact Protein Effect Variant Description Associated With Drug Resistance
Molecular Profile Protein Effect Treatment Approaches
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries