NUP98: Gene Detail - Cancer Knowledgebase (CKB)

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Gene Symbol

NUP98

Synonyms

ADIR2 | NUP196 | NUP96 | Nup98-96

Gene Description

NUP98, nucleoporin 98 and 96 precursor, forms part of the nuclear pore complex, which functions in transport across the nuclear membrane, and also plays a role in transcriptional regulation (PMID: 19577736, PMID: 21948299, PMID: 27889185) and regulation of histone methylation (PMID: 29284709). NUP98 fusions have been demonstrated in hematological malignancies, including acute myeloid leukemia (PMID: 19577736, PMID: 21948299, PMID: 27889185, PMID: 31558671) and acute promyelocytic leukemia (PMID: 32242976).

NCBI Gene ID	Chromosome	Map Location	Canonical Transcript	Gene Role
4928	11	11p15.4	NM_001365126	Oncogene (PMID: 30606230)

Additional content available in

CKB BOOST

Gene Variants 18
Category Variants 3
Molecular Profiles 20
Evidence 31
Clinical Trials 10

KEY FEATURES

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Genes

(50 Genes)

(2000+ Genes)

Gene Variants

Therapies

Limited

Global Drug Approvals

Drug Classes

Limited

Clinical Trials

Limited

Efficacy Evidence

Variant Tier Coding
(AMP/CAP/ASCO)

Advanced Search Capability

System Integration

More about our plans

The public access version, CKB CORE™, encompasses 50 cancer-related genes, and every quarter, a select group of genes are exchanged, focusing on a specific theme. Users can search CKB CORE™ via gene and gene variants. The web-based, subscription version, CKB BOOST™, includes more than 2000 cancer-related genes and is designed to interrogate the knowledgebase for specific data attributes while enabling a robust browse-like feature when the desired content is unknown.

Downloadable data from CKB is available using the FLEX version. CKB FLEX delivers CKB content as a flat file or JSON, enabling CKB data integration.

NUP98 - Gene Detail

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