OPCML - Gene Detail
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| Gene Symbol | OPCML | ||||||||||||
| Synonyms | IGLON1 | OBCAM | OPCM | ||||||||||||
| Gene Description | OPCML, opioid binding protein/cell adhesion molecule like, encodes an Ig domain-containing GPI-anchored cell adhesion molecule belonging to the IgLON family (PMID: 28407749) that promotes proteosomal degradation of receptor tyrosine kinases, resulting in negative regulation of downstream signaling (PMID: 22585860), and plays a role in regulating cell growth (PMID: 18714356, PMID: 22585860, PMID: 28407749). OPCML mutations have been identified in several tumor types (PMID: 31316070), including ovarian cancer (PMID: 12819783), and OPCML promoter methylation has been observed in various tumor types (PMID: 18714356), including colorectal cancer (PMID: 26175934) and ovarian cancer (PMID: 24327526). | ||||||||||||
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