Gene Detail
Contact
Missing content? – Request curation!
Request curation for specific Genes, Variants, or PubMed publications.
Have questions, comments, or suggestions? - Let us know!
Email us at : ckbsupport@genomenon.com
| Gene Symbol | PRKN | ||||||||||
| Synonyms | AR-JP | LPRS2 | PARK2 | PDJ | ||||||||||
| Gene Description | PRKN, parkin RBR E3 ubiquitin protein ligase, binds to E2 ubiquitin-conjugating enzymes thereby playing a role in protein degradation via ubiquitination and subsequently regulating various cellular processes, including mitochondrial homeostasis, anti-oxidative stress, and mitophagy (PMID: 10973942, PMID: 29529199). Loss of PRKN has been associated with colorectal carcinoma (PMID: 20696900) and loss of function mutations in PRKN have been associated with glioma (PMID: 25877876). | ||||||||||
|
|||||||||||
Additional content available in 
CKB BOOST
CKB BOOST
