PCM1: Gene Detail - Cancer Knowledgebase (CKB)

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Gene Symbol

PCM1

Synonyms

PTC4 | RET/PCM-1

Gene Description

PCM1, pericentriolar material 1, is a centriolar satellite protein, which recruits microtubule and dynactin-dependent proteins for appropriate microtubule organization (PMID: 12403812). A PCM1-RET fusion has been identified in papillary thyroid carcinoma (PMID: 10980597), PCM1 fusions with other genes have been observed in hematological cancers (PMID: 29797824, PMID: 26522767, PMID: 31085913, PMID: 29169164), and both overexpression and amplification of PCM1 have been linked to myeloid leukemias (PMID: 10980597, PMID: 23431203).

NCBI Gene ID	Chromosome	Map Location	Canonical Transcript	Gene Role
5108	8	8p22	NM_006197	Unknown

Additional content available in

CKB BOOST

Gene Variants 7
Category Variants 1
Molecular Profiles 7
Evidence 6
Clinical Trials 2

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Genes

(50 Genes)

(2000+ Genes)

Gene Variants

Therapies

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Global Drug Approvals

Drug Classes

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Clinical Trials

Limited

Efficacy Evidence

Variant Tier Coding
(AMP/CAP/ASCO)

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The public access version, CKB CORE™, encompasses 50 cancer-related genes, and every quarter, a select group of genes are exchanged, focusing on a specific theme. Users can search CKB CORE™ via gene and gene variants. The web-based, subscription version, CKB BOOST™, includes more than 2000 cancer-related genes and is designed to interrogate the knowledgebase for specific data attributes while enabling a robust browse-like feature when the desired content is unknown.

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PCM1 - Gene Detail

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