Gene Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@genomenon.com

Gene Symbol IRAK4
Synonyms IMD67 | IPD1 | IRAK-4 | NY-REN-64 | REN64
Gene Description IRAK4, interleukin 1 receptor associated kinase 4, encodes a kinase that interacts with Myd88, thereby playing a role in innate immunity via the IL-1/TLR pathway (PMID: 17470642, PMID: 30076215, PMID: 17337443) and participates in CD4+ T cell differentiation through IL-1 mediation (PMID: 19542468). Alternate isoforms of IRAK4 have been identified in myeloid malignancies (PMID: 31011167), and increased IRAK4 expression has been identified in pancreatic ductal adenocarcinoma (PMID: 29363544).
Additional content available in CKB BOOST