WAC: Gene Detail - Cancer Knowledgebase (CKB)

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Gene Symbol

WAC

Synonyms

BM-016 | DESSH | PRO1741 | Wwp4

Gene Description

WAC, WW domain containing adaptor with coiled-coil, plays a role in multiple cellular processes via protein-protein interactions (PMID: 11827461) including associations with SRSF2, a component of the mRNA splicing complex (PMID: 11827461), RNF20/40, which functions in ubiquitination, cell cycle control, RNA Polymerase II, and transcription (PMID: 21329877), VCIP135, which is involved in membrane fusion (PMID: 21811234), and components of the mTOR pathway, potentially acting as a regulator of autophagy (PMID: 26812014). An FGFR2-WAC fusion has been identified in cholangiocarcinoma (PMID: 32315234) and a WAC-RET fusion has been identified in lung adenocarcinoma (PMID: 29935851).

NCBI Gene ID	Chromosome	Map Location	Canonical Transcript	Gene Role
51322	10	10p12.1-p11.2	NM_016628	Unknown

Additional content available in

CKB BOOST

Gene Variants 3
Category Variants 0
Molecular Profiles 2
Evidence 15
Clinical Trials 0

KEY FEATURES

CKB CORE^TM

CKB BOOST^TM

CKB FLEX^TM

Access 50 genes & related content

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Scalable & flexible content integration for 2000+ genes

Genes

(50 Genes)

(2000+ Genes)

Gene Variants

Therapies

Limited

Global Drug Approvals

Drug Classes

Limited

Clinical Trials

Limited

Efficacy Evidence

Variant Tier Coding
(AMP/CAP/ASCO)

Advanced Search Capability

System Integration

More about our plans

The public access version, CKB CORE™, encompasses 50 cancer-related genes, and every quarter, a select group of genes are exchanged, focusing on a specific theme. Users can search CKB CORE™ via gene and gene variants. The web-based, subscription version, CKB BOOST™, includes more than 2000 cancer-related genes and is designed to interrogate the knowledgebase for specific data attributes while enabling a robust browse-like feature when the desired content is unknown.

Downloadable data from CKB is available using the FLEX version. CKB FLEX delivers CKB content as a flat file or JSON, enabling CKB data integration.

WAC - Gene Detail

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