POLK: Gene Detail - Cancer Knowledgebase (CKB)

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Gene Symbol

POLK

Synonyms

DINB1 | DINP | POLQ

Gene Description

POLK, DNA polymerase kappa, is a Y-family DNA polymerase that bypasses DNA damage through insertion and extension past the damaged nucleotides (PMID: 31374881), and is involved in mutagenesis (PMID: 12432099), DNA repair (PMID: 22658724, PMID: 20227374), and genome stability (PMID: 22157819). POLK mutations have been identified in prostate (PMID: 26046662), gastric (PMID: 27603496), and breast cancer (PMID: 26765445), Polk overexpression has been identified in lung cancer (PMID: 11454676) and glioma (PMID: 20164241), and decreased Polk expression has been reported in colorectal cancer (PMID: 17099721).

NCBI Gene ID	Chromosome	Map Location	Canonical Transcript	Gene Role
51426	5	5q13.3	NM_016218	Unknown

Additional content available in

CKB BOOST

Gene Variants 26
Category Variants 3
Molecular Profiles 26
Evidence 0
Clinical Trials 0

KEY FEATURES

CKB CORE^TM

CKB BOOST^TM

CKB FLEX^TM

Access 50 genes & related content

Access 2000+ genes & related content

Scalable & flexible content integration for 2000+ genes

Genes

(50 Genes)

(2000+ Genes)

Gene Variants

Therapies

Limited

Global Drug Approvals

Drug Classes

Limited

Clinical Trials

Limited

Efficacy Evidence

Variant Tier Coding
(AMP/CAP/ASCO)

Advanced Search Capability

System Integration

More about our plans

The public access version, CKB CORE™, encompasses 50 cancer-related genes, and every quarter, a select group of genes are exchanged, focusing on a specific theme. Users can search CKB CORE™ via gene and gene variants. The web-based, subscription version, CKB BOOST™, includes more than 2000 cancer-related genes and is designed to interrogate the knowledgebase for specific data attributes while enabling a robust browse-like feature when the desired content is unknown.

Downloadable data from CKB is available using the FLEX version. CKB FLEX delivers CKB content as a flat file or JSON, enabling CKB data integration.

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POLK - Gene Detail

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