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Gene Symbol PDGFB
Synonyms c-sis | IBGC5 | PDGF-2 | PDGF2 | SIS | SSV
Gene Description PDGFB, platelet derived growth factor subunit B, is a growth factor that signals through PDGFRs and plays a role in regulation of development, cell proliferation, cell migration (PMID: 18483217), and angiogenesis (PMID: 32235327). Overexpression of PDGFB has been implicated in several tumor types (PMID: 24359404), including oral squamous cell carcinoma (PMID: 32235327), and a fusion with COL1A1 has been reported in dermatofibrosarcoma protuberans (PMID: 31870844, PMID: 31353504).
NCBI Gene ID Chromosome Map Location Canonical Transcript Gene Role
5155 22 22q13.1 NM_002608 Oncogene (PMID: 30606230)
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