MED15: Gene Detail - Cancer Knowledgebase (CKB)

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Gene Symbol

MED15

Synonyms

ARC105 | CAG7A | CTG7A | PCQAP | TIG-1 | TIG1 | TNRC7

Gene Description

MED15, mediator complex subunit 15, encodes a subunit of the RNA polymerase II mediator complex and plays a role in transcriptional co-activation (PMID: 22195967, PMID: 31036407). Increased Med15 expression has been observed in prostate cancer (PMID: 24374838), breast cancer (PMID: 23014762), bladder cancer (PMID: 30127891), testicular germ cell tumors (PMID: 26377566), head and neck squamous cell carcinoma (PMID: 25791637), and a fusion with TFE3 has been identified in renal cell carcinoma (PMID: 31828108).

NCBI Gene ID	Chromosome	Map Location	Canonical Transcript	Gene Role
51586	22	22q11.21	NM_001003891	Unknown

Additional content available in

CKB BOOST

Gene Variants 11
Category Variants 2
Molecular Profiles 9
Evidence 0
Clinical Trials 0

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Variant Tier Coding
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The public access version, CKB CORE™, encompasses 50 cancer-related genes, and every quarter, a select group of genes are exchanged, focusing on a specific theme. Users can search CKB CORE™ via gene and gene variants. The web-based, subscription version, CKB BOOST™, includes more than 2000 cancer-related genes and is designed to interrogate the knowledgebase for specific data attributes while enabling a robust browse-like feature when the desired content is unknown.

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MED15 - Gene Detail

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