WWOX: Gene Detail - Cancer Knowledgebase (CKB)

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Gene Symbol

WWOX

Synonyms

D16S432E | DEE28 | EIEE28 | FOR | FRA16D | HHCMA56 | PRO0128 | SCAR12 | SDR41C1 | WOX1

Gene Description

WWOX, WW domain containing oxidoreductase, binds to several different proteins, including transcription factors to suppress transactivation, and thereby is involved in many cellular processes (PMID: 36271927, PMID: 24550385) such as glucose metabolism (PMID: 25012504), oxidative stress (PMID: 36364214), and apoptosis (PMID: 16219768), and acts as a dehydrogenase that catalyzes steroid substrates, likely playing a role in steroid metabolism (PMID: 36271927, PMID: 21476439). Deletion and/or promoter hypermethylation of WWOX has been identified in breast cancer (PMID: 30211123, PMID: 15674328) and lung cancer (PMID: 15674328, PMID: 20480411).

NCBI Gene ID	Chromosome	Map Location	Canonical Transcript	Gene Role
51741	16	16q23.1-q23.2	NM_016373	Unknown

Additional content available in

CKB BOOST

Gene Variants 4
Category Variants 0
Molecular Profiles 3
Evidence 0
Clinical Trials 0

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Variant Tier Coding
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WWOX - Gene Detail

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