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| Gene Symbol | POLD1 | ||||||||||
| Synonyms | CDC2 | CRCS10 | IMD120 | MDPL | POLD | ||||||||||
| Gene Description | POLD1, DNA polymerase delta 1, catalytic subunit, is the catalytic subunit and the largest of four subunits that form the DNA polymerase delta holoenzyme, which mediates DNA replication (PMID: 27320729) and repair (PMID: 30625304). Germline and somatic mutations in POLD1 have been identified in a variety of human cancers (PMID: 27320729), including colorectal cancer (PMID: 31769227) and lung cancer (PMID: 31673068), and may be associated with high tumor mutational burden and response to immunotherapy (PMID: 31741177, PMID: 31673068, PMID: 31415061, PMID: 30524909). | ||||||||||
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