POLG: Gene Detail - Cancer Knowledgebase (CKB)

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Gene Symbol

POLG

Synonyms

Gene Description

POLG, DNA polymerase gamma, catalytic subunit, encodes a mitochondrial DNA polymerase (PMID: 27814640), which is involved in the replication and repair of mitochondrial DNA (PMID: 27814640, PMID: 12673356), and plays an essential role in embryogenesis (PMID: 15888483). POLG1 mutations have been identified in breast cancer (PMID: 19629138), and a fusion with NTRK3 has been identified in gastrointestinal tumors (PMID: 33148671).

NCBI Gene ID	Chromosome	Map Location	Canonical Transcript	Gene Role
5428	15	15q26.1	NM_001126131	Tumor suppressor (PMID: 30606230)

Additional content available in

CKB BOOST

Gene Variants 11
Category Variants 2
Molecular Profiles 11
Evidence 0
Clinical Trials 0

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(50 Genes)

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Gene Variants

Therapies

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Global Drug Approvals

Drug Classes

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Clinical Trials

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Efficacy Evidence

Variant Tier Coding
(AMP/CAP/ASCO)

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The public access version, CKB CORE™, encompasses 50 cancer-related genes, and every quarter, a select group of genes are exchanged, focusing on a specific theme. Users can search CKB CORE™ via gene and gene variants. The web-based, subscription version, CKB BOOST™, includes more than 2000 cancer-related genes and is designed to interrogate the knowledgebase for specific data attributes while enabling a robust browse-like feature when the desired content is unknown.

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POLG - Gene Detail

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