DGCR8: Gene Detail - Cancer Knowledgebase (CKB)

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Gene Symbol

DGCR8

Synonyms

C22orf12 | DGCRK6 | Gy1 | pasha

Gene Description

DGCR8, DGCR8 microprocessor complex subunit, encodes a nuclear RNase III that interacts with Drosha, forming a complex that plays a role in primary microRNA processing (PMID: 16963499, PMID: 15531879, PMID: 15574589) and microRNA biogenesis, which is required for embryonic stem cell renewal (PMID: 17259983) and skin development (PMID: 19114655). Mutations in DGCR8 have been identified in follicular thyroid carcinoma (PMID: 34171097) and Wilm's tumor (PMID: 25670082, PMID: 25670083), and increased DGCR8 expression has been identified in invasive ductal breast carcinoma (PMID: 26804549).

NCBI Gene ID	Chromosome	Map Location	Canonical Transcript	Gene Role
54487	22	22q11.21	NM_022720	Unknown

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Gene Variants 1
Category Variants 0
Molecular Profiles 1
Evidence 0
Clinical Trials 0

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DGCR8 - Gene Detail

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