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Gene Symbol ATRX
Synonyms JMS | MRX52 | RAD54 | RAD54L | XH2 | XNP | ZNF-HX
Gene Description ATRX, ATRX chromatin remodeler, is in the SWI/SNF family of chromatin remodeling proteins and plays a role in DNA repair and telomere length (PMID: 36894374). ATRX loss and mutations have been identified in a high percentage of tumor types including glioma (PMID: 23249563; PMID: 26936505, PMID: 31908895) and copy number loss has also been observed in pancreatic neuroendocrine tumors (PMID: 30081149) and ovarian ependymomas (PMID: 29944970).
NCBI Gene ID Chromosome Map Location Canonical Transcript Gene Role
546 X Xq21.1 NM_000489 Tumor suppressor (PMID: 30606230)
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