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Gene Symbol | TET2 | ||||||||||
Synonyms | IMD75 | KIAA1546 | MDS | ||||||||||
Gene Description | TET2, methylcytosine dioxygenase TET2, is a member of the ten-eleven-translocation family of genes that plays a role in DNA methylation and is involved in hematopoesis (PMID: 26099018, PMID: 25510268, PMID: 27848178). TET2 has been identified as a tumor suppressor in hematological malignancies, and mutations in TET2 are common in hematological cancers including myelodysplastic syndrome, chronic myelomoncytic leukemia, and atypical CML (PMID: 26099018, PMID: 22240200, PMID: 30138727) and epigenetic dysregulation has been observed in glioblastoma (PMID: 29899831). | ||||||||||
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Molecular Profile | Protein Effect | Treatment Approaches |
---|---|---|
TET2 A1505T | loss of function | |
TET2 A1505T TET2 mut | ||
TET2 A855S | unknown | |
TET2 C1193W | loss of function - predicted | |
TET2 C1221Y | unknown | |
TET2 C1271W | unknown | |
TET2 C1273F | unknown | |
TET2 C1289F | unknown | |
TET2 C1374Y | unknown | |
TET2 C1378F | unknown | |
TET2 C1396R | unknown | |
TET2 C1642Wfs*49 | loss of function - predicted | |
TET2 C784fs | loss of function - predicted | |
TET2 C784S | unknown | |
TET2 D1143fs | loss of function - predicted | |
TET2 D1242V | loss of function - predicted | |
TET2 D1384A | loss of function - predicted | |
TET2 D1384V | unknown | |
TET2 D1427Y | unknown | |
TET2 D162fs | loss of function - predicted | |
TET2 D545Tfs*10 | loss of function - predicted | |
TET2 del | loss of function | |
DNMT3A del TET2 del | ||
TET2 E1207K | unknown | |
TET2 T1063Nfs*5 TET2 E1207K | ||
TET2 E1323* | loss of function - predicted | |
TET2 E1477* | loss of function - predicted | |
TET2 E1879A | unknown | |
TET2 E320* | loss of function - predicted | |
TET2 F1300I | unknown | |
TET2 F1377A | loss of function - predicted | |
TET2 G1256D | loss of function - predicted | |
TET2 G1275E | unknown | |
TET2 G1288S | unknown | |
TET2 G1361S | unknown | |
TET2 G1814* | unknown | |
TET2 G1861R | loss of function | |
TET2 G355D | unknown | |
TET2 H1219N | unknown | |
TET2 H1219Y | unknown | |
TET2 H1380L | unknown | |
TET2 H1380Y | unknown | |
TET2 H1382Y | loss of function - predicted | |
TET2 H1778R | no effect - predicted | |
TET2 H1868D | unknown | |
TET2 H1881Q | loss of function - predicted | |
TET2 H1881R | loss of function - predicted | |
TET2 H1881Y | unknown | |
TET2 H1904R | loss of function - predicted | |
TET2 H222Tfs*3 | loss of function - predicted | |
TET2 H924R | unknown | |
TET2 I1175S | unknown | |
TET2 I1762V | no effect | |
TET2 I1873T | loss of function - predicted | |
TET2 I249fs | loss of function - predicted | |
TET2 I812fs | loss of function - predicted | |
TET2 inact mut | loss of function | |
TET2 inact mut TP53 wild-type | ||
TET2 K1171fs | loss of function - predicted | |
TET2 K450* | loss of function - predicted | |
TET2 K67fs | loss of function - predicted | |
TET2 L1322P | unknown | |
TET2 L1326S | unknown | |
TET2 L1514H | unknown | |
TET2 L1721W | no effect - predicted | |
TET2 L1801F | unknown | |
TET2 L34F | unknown | |
TET2 L360W | unknown | |
TET2 loss | loss of function | |
TET2 loss TP53 wild-type | ||
DNMT3A loss TET2 loss | ||
FLT3 exon 14 ins TET2 loss | ||
DNMT3A loss FLT3 exon 14 ins TET2 loss | ||
JAK2 V617F TET2 loss | ||
TET2 M1293A | unknown | |
TET2 M1701I | unknown | |
TET2 mutant | unknown | |
DNMT3A mut TET2 mut | ||
FLT3 exon 14 ins TET2 mut | ||
DNMT3A mut FLT3 exon 14 ins TET2 mut | ||
TET2 N1387A | loss of function - predicted | |
TET2 N870S | unknown | |
TET2 P1617H | loss of function | |
TET2 P1723S | no effect - predicted | |
TET2 P174H | unknown | |
TET2 P1889H | unknown | |
TET2 P29R | unknown | |
TET2 P363L | unknown | |
TET2 P929Lfs*24 | loss of function - predicted | |
TET2 Q1084P | unknown | |
TET2 Q1191* | loss of function - predicted | |
TET2 Q1389* | loss of function - predicted | |
TET2 Q1414* | loss of function - predicted | |
TET2 Q1524H | unknown | |
TET2 Q1540K | unknown | |
TET2 Q1624H | unknown | |
TET2 Q317fs | loss of function - predicted | |
TET2 Q591* | loss of function - predicted | |
TET2 Q642* | loss of function - predicted | |
TET2 Q652* | loss of function - predicted | |
TET2 Q690* | loss of function - predicted | |
TET2 Q701* | loss of function - predicted | |
TET2 Q742* | loss of function - predicted | |
TET2 Q876* | loss of function - predicted | |
TET2 Q891fs | loss of function - predicted | |
TET2 Q916* | loss of function - predicted | |
TET2 Q958Rfs*49 | loss of function - predicted | |
TET2 Q958Rfs*49 TET2 R1179Efs*47 | ||
TET2 R1067* | loss of function - predicted | |
TET2 R1179Efs*47 | loss of function - predicted | |
TET2 R1261G | loss of function - predicted | |
TET2 R1261H | unknown | |
TET2 R1262A | loss of function - predicted | |
TET2 R1302G | loss of function - predicted | |
TET2 R1359C | unknown | |
TET2 R1359H | unknown | |
TET2 R1359S | unknown | |
TET2 R1404* | loss of function - predicted | |
TET2 R1440fs | loss of function - predicted | |
TET2 R1452* | loss of function - predicted | |
TET2 R1465* | loss of function - predicted | |
TET2 R1516* | loss of function - predicted | |
TET2 R1572Q | unknown | |
TET2 R1896M | loss of function - predicted | |
TET2 R1896S | loss of function | |
TET2 R2000I | unknown | |
TET2 R506* | loss of function - predicted | |
TET2 R550* | loss of function - predicted | |
TET2 S1039L | unknown | |
TET2 S1109F | unknown | |
TET2 S1203R | unknown | |
TET2 S1290A | unknown | |
TET2 S1303N | unknown | |
TET2 S1369* | loss of function - predicted | |
TET2 S1607L | unknown | |
TET2 S1758* | loss of function - predicted | |
TET2 S1870L | unknown | |
TET2 S354* | loss of function - predicted | |
TET2 S358G | unknown | |
TET2 S393Lfs*34 | loss of function - predicted | |
TET2 S792* | loss of function - predicted | |
TET2 S833Ffs*8 | loss of function - predicted | |
TET2 S835* | loss of function - predicted | |
TET2 T1063Nfs*5 | loss of function - predicted | |
TET2 T1884A | loss of function - predicted | |
TET2 T759P | unknown | |
TET2 V1006Gfs*3 | loss of function - predicted | |
TET2 V1199E | unknown | |
BRAF V600E TET2 V1199E | ||
TET2 V1718L | unknown | |
TET2 W1198* | loss of function - predicted | |
TET2 W1291R | loss of function | |
TET2 W1291_N1296delinsGGSGGS | loss of function - predicted | |
TET2 wild-type | no effect | |
TET2 Y1294A | unknown | |
TET2 Y1295A | unknown | |
TET2 Y1902A | loss of function - predicted | |
TET2 Y867H | unknown |