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Gene Symbol TET2
Synonyms IMD75 | KIAA1546 | MDS
Gene Description TET2, methylcytosine dioxygenase TET2, is a member of the ten-eleven-translocation family of genes that plays a role in DNA methylation and is involved in hematopoesis (PMID: 26099018, PMID: 25510268, PMID: 27848178). TET2 has been identified as a tumor suppressor in hematological malignancies, and mutations in TET2 are common in hematological cancers including myelodysplastic syndrome, chronic myelomoncytic leukemia, and atypical CML (PMID: 26099018, PMID: 22240200, PMID: 30138727) and epigenetic dysregulation has been observed in glioblastoma (PMID: 29899831).

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Molecular Profile Protein Effect Treatment Approaches
TET2 A1505T loss of function
TET2 A1505T TET2 mut
TET2 A855S unknown
TET2 C1193W loss of function - predicted
TET2 C1221Y unknown
TET2 C1271W unknown
TET2 C1273F unknown
TET2 C1289F unknown
TET2 C1374Y unknown
TET2 C1378F unknown
TET2 C1396R unknown
TET2 C1642Wfs*49 loss of function - predicted
TET2 C784fs loss of function - predicted
TET2 C784S unknown
TET2 D1143fs loss of function - predicted
TET2 D1242V loss of function - predicted
TET2 D1384A loss of function - predicted
TET2 D1384V unknown
TET2 D1427Y unknown
TET2 D162fs loss of function - predicted
TET2 D545Tfs*10 loss of function - predicted
TET2 del loss of function
DNMT3A del TET2 del
TET2 E1207K unknown
TET2 T1063Nfs*5 TET2 E1207K
TET2 E1323* loss of function - predicted
TET2 E1477* loss of function - predicted
TET2 E1879A unknown
TET2 E320* loss of function - predicted
TET2 F1300I unknown
TET2 F1377A loss of function - predicted
TET2 G1256D loss of function - predicted
TET2 G1275E unknown
TET2 G1288S unknown
TET2 G1361S unknown
TET2 G1814* unknown
TET2 G1861R loss of function
TET2 G355D unknown
TET2 H1219N unknown
TET2 H1219Y unknown
TET2 H1380L unknown
TET2 H1380Y unknown
TET2 H1382Y loss of function - predicted
TET2 H1778R no effect - predicted
TET2 H1868D unknown
TET2 H1881Q loss of function - predicted
TET2 H1881R loss of function - predicted
TET2 H1881Y unknown
TET2 H1904R loss of function - predicted
TET2 H222Tfs*3 loss of function - predicted
TET2 H924R unknown
TET2 I1175S unknown
TET2 I1762V no effect
TET2 I1873T loss of function - predicted
TET2 I249fs loss of function - predicted
TET2 I812fs loss of function - predicted
TET2 inact mut loss of function
TET2 inact mut TP53 wild-type
TET2 K1171fs loss of function - predicted
TET2 K450* loss of function - predicted
TET2 K67fs loss of function - predicted
TET2 L1322P unknown
TET2 L1326S unknown
TET2 L1514H unknown
TET2 L1721W no effect - predicted
TET2 L1801F unknown
TET2 L34F unknown
TET2 L360W unknown
TET2 loss loss of function
TET2 loss TP53 wild-type
DNMT3A loss TET2 loss
FLT3 exon 14 ins TET2 loss
DNMT3A loss FLT3 exon 14 ins TET2 loss
JAK2 V617F TET2 loss
TET2 M1293A unknown
TET2 M1701I unknown
TET2 mutant unknown
DNMT3A mut TET2 mut
FLT3 exon 14 ins TET2 mut
DNMT3A mut FLT3 exon 14 ins TET2 mut
TET2 N1387A loss of function - predicted
TET2 N870S unknown
TET2 P1617H loss of function
TET2 P1723S no effect - predicted
TET2 P174H unknown
TET2 P1889H unknown
TET2 P29R unknown
TET2 P363L unknown
TET2 P929Lfs*24 loss of function - predicted
TET2 Q1084P unknown
TET2 Q1191* loss of function - predicted
TET2 Q1389* loss of function - predicted
TET2 Q1414* loss of function - predicted
TET2 Q1524H unknown
TET2 Q1540K unknown
TET2 Q1624H unknown
TET2 Q317fs loss of function - predicted
TET2 Q591* loss of function - predicted
TET2 Q642* loss of function - predicted
TET2 Q652* loss of function - predicted
TET2 Q690* loss of function - predicted
TET2 Q701* loss of function - predicted
TET2 Q742* loss of function - predicted
TET2 Q876* loss of function - predicted
TET2 Q891fs loss of function - predicted
TET2 Q916* loss of function - predicted
TET2 Q958Rfs*49 loss of function - predicted
TET2 Q958Rfs*49 TET2 R1179Efs*47
TET2 R1067* loss of function - predicted
TET2 R1179Efs*47 loss of function - predicted
TET2 R1261G loss of function - predicted
TET2 R1261H unknown
TET2 R1262A loss of function - predicted
TET2 R1302G loss of function - predicted
TET2 R1359C unknown
TET2 R1359H unknown
TET2 R1359S unknown
TET2 R1404* loss of function - predicted
TET2 R1440fs loss of function - predicted
TET2 R1452* loss of function - predicted
TET2 R1465* loss of function - predicted
TET2 R1516* loss of function - predicted
TET2 R1572Q unknown
TET2 R1896M loss of function - predicted
TET2 R1896S loss of function
TET2 R2000I unknown
TET2 R506* loss of function - predicted
TET2 R550* loss of function - predicted
TET2 S1039L unknown
TET2 S1109F unknown
TET2 S1203R unknown
TET2 S1290A unknown
TET2 S1303N unknown
TET2 S1369* loss of function - predicted
TET2 S1607L unknown
TET2 S1758* loss of function - predicted
TET2 S1870L unknown
TET2 S354* loss of function - predicted
TET2 S358G unknown
TET2 S393Lfs*34 loss of function - predicted
TET2 S792* loss of function - predicted
TET2 S833Ffs*8 loss of function - predicted
TET2 S835* loss of function - predicted
TET2 T1063Nfs*5 loss of function - predicted
TET2 T1884A loss of function - predicted
TET2 T759P unknown
TET2 V1006Gfs*3 loss of function - predicted
TET2 V1199E unknown
BRAF V600E TET2 V1199E
TET2 V1718L unknown
TET2 W1198* loss of function - predicted
TET2 W1291R loss of function
TET2 W1291_N1296delinsGGSGGS loss of function - predicted
TET2 wild-type no effect
TET2 Y1294A unknown
TET2 Y1295A unknown
TET2 Y1902A loss of function - predicted
TET2 Y867H unknown