RFWD3 - Gene Detail
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| Gene Symbol | RFWD3 | ||||||||||||
| Synonyms | FANCW | RNF201 | ||||||||||||
| Gene Description | RFWD3, ring finger and WD repeat domain 3, is an E3 ubiquitin ligase that plays a role in response to DNA damage and DNA repair (PMID: 21558276, PMID: 28575658, PMID: 20173098, PMID: 26474068), and in DNA replication (PMID: 21504906, PMID: 30530694). Germline RFWD3 mutations are associated with Fanconi anemia (PMID: 28691929), and overexpression of Rfwd3 has been observed in colorectal cancer (PMID: 34712656), bladder cancer (PMID: 36458571), hepatocellular carcinoma (PMID: 36744161), and glioblastoma (PMID: 40700452). | ||||||||||||
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