PBRM1 - Gene Detail

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Gene Symbol PBRM1
Synonyms BAF180 | PB1 | RCC | SMARCH1
Gene Description PBRM1, polybromo 1, is a member of the PBAF subunit (PMID: 32303701) of the SWI/SNF complex, which functions in chromatin remodeling to modulate gene expression (PMID: 23867514). PBRM1 is frequently mutated in clear cell renal cell carcinoma (PMID: 19084573, PMID: 31861590).
NCBI Gene ID Chromosome Map Location Canonical Transcript Gene Role
55193 3 3p21.1 NM_018313 Tumor suppressor (PMID: 30606230)

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Variant Impact Protein Effect Variant Description Associated With Drug Resistance
Variant Impact Protein Effect Variant Description Associated With Drug Resistance
Molecular Profile Protein Effect Treatment Approaches
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries