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Gene Symbol | FBXW7 | ||||||||||
Synonyms | AGO | CDC4 | DEDHIL | FBW6 | FBW7 | FBX30 | FBXO30 | FBXW6 | hAgo | hCdc4 | SEL-10 | SEL10 | ||||||||||
Gene Description | FBXW7, F-box/WD repeat-containing protein 7, is part of the SCF E3 ubiquitin-protein ligase complex, which plays a role in the degradation of proteins involved in cell division and cell growth (PMID: 17909001, PMID: 22673505). FBXW7 mutations have been associated with cholangiocarcinoma and acute lymphocytic leukemia (PMID: 17909001) and have been identified in many other cancers, including colorectal (PMID: 28424412), endometrial, and stomach cancer (PMID: 17909001). | ||||||||||
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Molecular Profile | Protein Effect | Treatment Approaches |
---|---|---|
FBXW7 A481V | unknown | |
FBXW7 A503T | unknown | |
FBXW7 A503V | unknown | |
FBXW7 C386W | unknown | |
FBXW7 C453fs | loss of function - predicted | mTORC1 Inhibitor |
FBXW7 D135Y | unknown | |
FBXW7 D362* | loss of function - predicted | |
FBXW7 D440N | unknown | |
FBXW7 D480N | loss of function - predicted | |
FBXW7 D480Y | unknown | |
FBXW7 D510E | loss of function | |
FBXW7 D520G | unknown | |
FBXW7 D520H | unknown | |
FBXW7 D520N | unknown | |
FBXW7 D520V | unknown | |
FBXW7 D520Y | unknown | |
FBXW7 D527G | loss of function - predicted | |
FBXW7 D550Mfs*6 | unknown | |
FBXW7 D560G | unknown | |
FBXW7 D600H | unknown | |
FBXW7 D600Y | unknown | |
FBXW7 del | loss of function | mTORC1 Inhibitor |
FBXW7 E113D | unknown | |
FBXW7 E117del | unknown | |
FBXW7 E192A | unknown | |
FBXW7 E248D | unknown | |
FBXW7 E287D | unknown | |
FBXW7 E287K | unknown | |
FBXW7 E287Q | unknown | |
FBXW7 E287V | unknown | |
FBXW7 E369* | loss of function - predicted | mTORC1 Inhibitor |
FBXW7 G16delinsVR | no effect - predicted | |
FBXW7 G378Dfs*6 | loss of function - predicted | |
FBXW7 G397D | unknown | |
FBXW7 G411S | unknown | |
FBXW7 G422C | unknown | |
FBXW7 G423* | loss of function - predicted | mTORC1 Inhibitor |
FBXW7 G423A | unknown | |
FBXW7 G423R | unknown | |
FBXW7 G423V | loss of function | |
FBXW7 G437E | unknown | |
FBXW7 G437R | unknown | |
FBXW7 G437V | unknown | |
FBXW7 G477S | unknown | |
FBXW7 G499Vfs*25 | loss of function - predicted | mTORC1 Inhibitor |
FBXW7 G517E | unknown | |
FBXW7 G579A | unknown | |
FBXW7 G579W | unknown | |
FBXW7 G597E | unknown | |
FBXW7 G667fs | unknown | |
FBXW7 G670fs | unknown | |
FBXW7 H379R | unknown | |
FBXW7 H382N | unknown | |
FBXW7 H420Y | unknown | |
FBXW7 H460R | loss of function - predicted | mTORC1 Inhibitor |
FBXW7 H460Y | unknown | |
FBXW7 H468R | loss of function | mTORC1 Inhibitor |
FBXW7 H470P | unknown | |
FBXW7 H500D | unknown | |
FBXW7 H500R | unknown | |
FBXW7 H500Y | unknown | |
FBXW7 I347M | unknown | |
FBXW7 I435fs | loss of function - predicted | mTORC1 Inhibitor |
FBXW7 I563T | unknown | |
FBXW7 inact mut | loss of function | mTORC1 Inhibitor |
FBXW7 K11R | loss of function - predicted | mTORC1 Inhibitor |
FBXW7 K167T | unknown | |
FBXW7 K239Q | unknown | |
FBXW7 K299fs | loss of function - predicted | mTORC1 Inhibitor |
FBXW7 K404E | unknown | |
FBXW7 K444fs | loss of function - predicted | mTORC1 Inhibitor |
FBXW7 L301P | unknown | |
FBXW7 L320I | unknown | |
FBXW7 L443F | loss of function - predicted | |
FBXW7 L443H | unknown | |
FBXW7 loss | loss of function | mTORC1 Inhibitor |
FBXW7 mutant | unknown | |
FBXW7 P247T | unknown | |
FBXW7 P285H | unknown | |
FBXW7 P298L | unknown | |
FBXW7 positive | unknown | |
FBXW7 Q127* | loss of function - predicted | |
FBXW7 Q275* | loss of function - predicted | mTORC1 Inhibitor |
FBXW7 Q306* | loss of function - predicted | mTORC1 Inhibitor |
FBXW7 Q47* | loss of function - predicted | mTORC1 Inhibitor |
FBXW7 Q631* | unknown | |
FBXW7 R14* | loss of function - predicted | |
FBXW7 R14Q | unknown | |
FBXW7 R179C | unknown | |
FBXW7 R179H | unknown | |
FBXW7 R222* | loss of function - predicted | mTORC1 Inhibitor |
FBXW7 R224* | loss of function - predicted | mTORC1 Inhibitor |
FBXW7 R224L | unknown | |
FBXW7 R224Q | unknown | |
FBXW7 R278* | loss of function - predicted | mTORC1 Inhibitor |
FBXW7 R367* | loss of function - predicted | mTORC1 Inhibitor |
FBXW7 R367P | unknown | |
FBXW7 R393* | loss of function - predicted | mTORC1 Inhibitor |
FBXW7 R393Q | unknown | |
FBXW7 R441G | unknown | |
FBXW7 R441L | unknown | |
FBXW7 R441Q | unknown | |
FBXW7 R441W | unknown | |
FBXW7 R465C | loss of function | mTORC1 Inhibitor |
FBXW7 R465G | unknown | |
FBXW7 R465H | loss of function | mTORC1 Inhibitor |
FBXW7 R465L | loss of function | mTORC1 Inhibitor |
FBXW7 R465P | loss of function - predicted | mTORC1 Inhibitor |
FBXW7 R465S | unknown | |
FBXW7 R465Y | loss of function - predicted | mTORC1 Inhibitor |
FBXW7 R473fs | loss of function - predicted | mTORC1 Inhibitor |
FBXW7 R479* | loss of function - predicted | mTORC1 Inhibitor |
FBXW7 R479G | loss of function - predicted | mTORC1 Inhibitor |
FBXW7 R479H | loss of function | mTORC1 Inhibitor |
FBXW7 R479L | loss of function | mTORC1 Inhibitor |
FBXW7 R479P | loss of function - predicted | mTORC1 Inhibitor |
FBXW7 R479Q | loss of function | mTORC1 Inhibitor |
FBXW7 R479S | unknown | |
FBXW7 R505C | loss of function | mTORC1 Inhibitor |
FBXW7 R505G | loss of function - predicted | |
FBXW7 R505H | unknown | |
FBXW7 R505L | loss of function - predicted | mTORC1 Inhibitor |
FBXW7 R505P | unknown | |
FBXW7 R505S | unknown | |
FBXW7 R543fs | unknown | |
FBXW7 R658* | unknown | |
FBXW7 R658Q | unknown | |
FBXW7 R689Q | unknown | |
FBXW7 R689W | loss of function - predicted | |
FBXW7 S227A | loss of function | mTORC1 Inhibitor |
FBXW7 S282* | loss of function - predicted | mTORC1 Inhibitor |
FBXW7 S396fs | loss of function - predicted | |
FBXW7 S396N | unknown | |
FBXW7 S398F | unknown | |
FBXW7 S426L | unknown | |
FBXW7 S462P | loss of function | mTORC1 Inhibitor |
FBXW7 S462Y | unknown | |
FBXW7 S476I | unknown | |
FBXW7 S476R | unknown | |
FBXW7 S516N | unknown | |
FBXW7 S516R | unknown | |
FBXW7 S546L | unknown | |
FBXW7 S546P | unknown | |
FBXW7 S558F | unknown | |
FBXW7 S562L | unknown | |
FBXW7 S582L | unknown | |
FBXW7 S582P | unknown | |
FBXW7 S601F | unknown | |
FBXW7 S668fs | unknown | |
FBXW7 S668Vfs*39 | unknown | |
FBXW7 S86L | unknown | |
FBXW7 T144R | unknown | |
FBXW7 T15_G16insP | loss of function | mTORC1 Inhibitor |
FBXW7 T15_G16insTP | unknown | |
FBXW7 T165fs | loss of function - predicted | mTORC1 Inhibitor |
FBXW7 T385I | unknown | |
FBXW7 T385K | unknown | |
FBXW7 T385P | unknown | |
FBXW7 T416A | unknown | |
FBXW7 T532I | unknown | |
FBXW7 T532P | unknown | |
FBXW7 V154I | no effect - predicted | |
FBXW7 V265I | unknown | |
FBXW7 V418M | no effect - predicted | |
FBXW7 V464E | unknown | |
FBXW7 V464M | unknown | |
FBXW7 V504I | unknown | |
FBXW7 V514F | loss of function - predicted | |
FBXW7 W237* | loss of function - predicted | mTORC1 Inhibitor |
FBXW7 W244* | loss of function - predicted | mTORC1 Inhibitor |
FBXW7 W406R | unknown | |
FBXW7 W425C | loss of function | |
FBXW7 W425R | loss of function | mTORC1 Inhibitor |
FBXW7 W446C | unknown | |
FBXW7 W486* | loss of function - predicted | mTORC1 Inhibitor |
FBXW7 W526L | unknown | |
FBXW7 W526R | unknown | |
FBXW7 W606* | unknown | |
FBXW7 W649* | unknown | |
FBXW7 wild-type | no effect | |
FBXW7 Y519C | unknown | |
FBXW7 Y545* | unknown | |
FBXW7 Y545C | loss of function - predicted |