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PPP6C - Gene Detail

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Gene Symbol PPP6C
Synonyms PP6 | PP6C
Gene Description PPP6C, protein phosphatase 6 catalytic subunit, encodes the catalytic subunit of the trimeric holoenzyme protein phosphatase 6 (PP6), which regulates dephosphorylation of Aurora Kinase A (PMID: 24336958), and plays a role in DNA damage repair, chromosome segregation, and negative regulation of inflammatory signaling (PMID: 30036567, PMID: 26868000, PMID: 21451261). PPP6C mutations are associated with melanoma (PMID: 24336958, PMID: 23729733), and basal cell carcinoma (PMID: 26950094), and upregulation of PPP6C has been demonstrated in glioblastoma (PMID: 22158480).
NCBI Gene ID Chromosome Map Location Canonical Transcript Gene Role
5537 9 9q33.3 NM_002721 Tumor suppressor (PMID: 30606230)
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