CHD7: Gene Detail - Cancer Knowledgebase (CKB)

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Gene Symbol

CHD7

Synonyms

CRG | HH5 | IS3 | KAL5

Gene Description

CHD7, chromodomain helicase DNA binding protein 7, encodes an ATP-dependent chromatin remodeling enzyme that plays a role in regulating gene expression in embryonic stem cells during development (PMID: 20657823), neural crest formation (PMID: 20130577), neural progenitors in the central nervous system (PMID: 30108144, PMID: 29440260, PMID: 26928066), and ribosomal RNA biogenesis (PMID: 20591827). Increased CHD7 expression has been observed in glioma (PMID: 30850678) and breast cancer (PMID: 28649742), and a fusion with BEND2 has been identified in a pancreatic neuroendocrine tumor (PMID: 31160355).

NCBI Gene ID	Chromosome	Map Location	Canonical Transcript	Gene Role
55636	8	8q12.2	NM_017780	Unknown

Additional content available in

CKB BOOST

Gene Variants 11
Category Variants 2
Molecular Profiles 11
Evidence 0
Clinical Trials 0

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Genes

(50 Genes)

(2000+ Genes)

Gene Variants

Therapies

Limited

Global Drug Approvals

Drug Classes

Limited

Clinical Trials

Limited

Efficacy Evidence

Variant Tier Coding
(AMP/CAP/ASCO)

Advanced Search Capability

System Integration

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The public access version, CKB CORE™, encompasses 50 cancer-related genes, and every quarter, a select group of genes are exchanged, focusing on a specific theme. Users can search CKB CORE™ via gene and gene variants. The web-based, subscription version, CKB BOOST™, includes more than 2000 cancer-related genes and is designed to interrogate the knowledgebase for specific data attributes while enabling a robust browse-like feature when the desired content is unknown.

Downloadable data from CKB is available using the FLEX version. CKB FLEX delivers CKB content as a flat file or JSON, enabling CKB data integration.

CHD7 - Gene Detail

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