INTS8: Gene Detail - Cancer Knowledgebase (CKB)

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Gene Symbol

INTS8

Synonyms

C8orf52 | INT8 | NEDCHS

Gene Description

INTS8, integrator complex subunit 8, encodes a subunit of the RNA polymerase II (RNAPII)-associated integrator complex (PMID: 16239144, PMID: 25882383), which plays a role in transcriptome integrity maintenance (PMID: 28542170) and transcriptional repression (PMID: 32966759). INTS8 mutations have been identified in peripheral T cell lymphoma (PMID: 26536348), increased INTS8 expression has been observed in hepatocellular carcinoma (PMID: 30881114, PMID: 27567667), and INTS8 fusions have been identified in breast cancer (PMID: 29617662) and melanoma (PMID: 29099951).

NCBI Gene ID	Chromosome	Map Location	Canonical Transcript	Gene Role
55656	8	8q22.1	NM_017864	Unknown

Additional content available in

CKB BOOST

Gene Variants 15
Category Variants 2
Molecular Profiles 14
Evidence 0
Clinical Trials 0

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Variant Tier Coding
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INTS8 - Gene Detail

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