PRKACA: Gene Detail - Cancer Knowledgebase (CKB)

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Gene Symbol

PRKACA

Synonyms

CAFD1 | PKACA | PPNAD4

Gene Description

PRKACA, protein kinase cAMP-activated catalytic subunit alpha, encodes the catalytic subunit of protein kinase A, which activates cAMP-dependent signaling pathways and is involved in diverse biological processes including cardiovascular and adrenal cortex functions (PMID: 26042218, PMID: 26687711, PMID: 29205368). PRKACA mutations have been identified in cardiac (PMID: 28369983) and adrenal (PMID: 26042218) tumors, and a DNAJB1-PRKACA fusion has been identified in fibrolamellar hepatocellular carcinoma (PMID: 24578576), and in pancreatic and bile duct cancer (PMID: 31676785).

NCBI Gene ID	Chromosome	Map Location	Canonical Transcript	Gene Role
5566	19	19p13.12	NM_002730	Oncogene (PMID: 30606230)

Additional content available in

CKB BOOST

Gene Variants 13
Category Variants 4
Molecular Profiles 11
Evidence 1
Clinical Trials 0

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Variant Tier Coding
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The public access version, CKB CORE™, encompasses 50 cancer-related genes, and every quarter, a select group of genes are exchanged, focusing on a specific theme. Users can search CKB CORE™ via gene and gene variants. The web-based, subscription version, CKB BOOST™, includes more than 2000 cancer-related genes and is designed to interrogate the knowledgebase for specific data attributes while enabling a robust browse-like feature when the desired content is unknown.

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PRKACA - Gene Detail

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