Welcome to CKB CORE's new home! Please be sure to update any bookmarks you may have.
×

Gene Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@genomenon.com

Gene Symbol PRKACA
Synonyms CAFD1 | PKACA | PPNAD4
Gene Description PRKACA, protein kinase cAMP-activated catalytic subunit alpha, encodes the catalytic subunit of protein kinase A, which activates cAMP-dependent signaling pathways and is involved in diverse biological processes including cardiovascular and adrenal cortex functions (PMID: 26042218, PMID: 26687711, PMID: 29205368). PRKACA mutations have been identified in cardiac (PMID: 28369983) and adrenal (PMID: 26042218) tumors, and a DNAJB1-PRKACA fusion has been identified in fibrolamellar hepatocellular carcinoma (PMID: 24578576), and in pancreatic and bile duct cancer (PMID: 31676785).
Additional content available in CKB BOOST