Gene Detail
Contact
Missing content? – Request curation!
Request curation for specific Genes, Variants, or PubMed publications.
Have questions, comments, or suggestions? - Let us know!
Email us at : ckbsupport@genomenon.com
| Gene Symbol | PAG1 | ||||||||||
| Synonyms | CBP | PAG | ||||||||||
| Gene Description | PAG1, phosphoprotein membrane anchor with glycosphingolipid microdomains 1, encodes a transmembrane adaptor protein found in lipid rafts, which binds to Csk to form a complex that negatively regulates the signaling of Src family kinases (PMID: 24213579, PMID: 18498747), thereby playing a role in immunoreceptor signaling including inhibition of T-cell activity (PMID: 12612075) and regulation of mast cell signaling (PMID: 25246632). A fusion with PAG1 and ABL2 has been identified in acute lymphoblastic leukemia (PMID: 31255796). | ||||||||||
|
|||||||||||
Additional content available in 
CKB BOOST
CKB BOOST
