MAP2K1 - Gene Detail

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Gene Symbol MAP2K1
Synonyms CFC3 | MAPKK1 | MEK1 | MEL | MKK1 | PRKMK1
Gene Description MAP2K1 (MEK1), mitogen-activated protein kinase kinase 1, is a serine-threonine kinase, which activates the RAS-RAF-MEK-ERK pathway in cell proliferation and differentiation (PMID: 22753777). MAP2K1 (MEK1) activating mutations have been identified in a number of solid tumor types including, melanoma (PMID: 29753091), colorectal (PMID: 28819429), lung adenocarcinoma (PMID: 25351745, PMID: 32361034), histiocytic sarcoma (PMID: 29768143), and Map2k1 mutations are often associated with resistance to Mek and Raf inhibition (PMID: 29753091).
NCBI Gene ID Chromosome Map Location Canonical Transcript Gene Role
5604 15 15q22.31 NM_002755 Oncogene (PMID: 30606230)

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