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PRLR - Gene Detail

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Gene Symbol PRLR
Synonyms HPRL | hPRLrI | MFAB | RI-PRLR
Gene Description PRLR, prolactin receptor, is a member of the type 1 cytokine receptor superfamily that binds the hormone, prolactin, to activate Jak2/Stat5, MAPK, and PI3K pathways for control of lactation (PMID: 28377489, PMID: 27107001). Overexpression of PRLR has been observed in multiple subtypes of breast cancer (PMID: 28377489) and was associated with increased survival in triple-ngeative breast cancer patients (PMID: 32199279).
NCBI Gene ID Chromosome Map Location Canonical Transcript Gene Role
5618 5 5p13.2 NM_000949 Unknown
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