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Clinical Trial	Phase	Therapies	Title	Recruitment Status	Covered Countries	Other Countries
NCT01870726	Phase Ib/II	Buparlisib + Capmatinib	Safety and Efficacy of INC280 and Buparlisib (BKM120) in Patients With Recurrent Gliobastoma	Terminated	USA \| NLD \| ESP \| DEU \| CHE	0
NCT06239467	Phase I	OKI-219 + Trastuzumab OKI-219 Fulvestrant + OKI-219	First-in-Human Study of OKI-219 in Advanced Solid Tumors and Advanced Breast Cancer (PIKture-01)	Recruiting	USA \| FRA \| ESP \| BEL	1
NCT04493853	Phase III	Abiraterone + Capivasertib Abiraterone	Capivasertib+Abiraterone as Treatment for Patients With Metastatic Hormone-sensitive Prostate Cancer and PTEN Deficiency (CAPItello-281)	Active, not recruiting	USA \| TUR \| SVK \| POL \| NLD \| ISR \| GBR \| FRA \| ESP \| DEU \| CZE \| CAN \| BRA \| BGR \| BEL \| AUT \| AUS \| ARG	14
NCT04592237	Phase II	Niraparib Cabazitaxel + Carboplatin + Cetrelimab Cetrelimab + Niraparib	Cabazitaxel, Carboplatin, and Cetrelimab Followed by Niraparib With or Without Cetrelimab for the Treatment of Aggressive Variant Metastatic Prostate Cancer	Active, not recruiting	USA	0
NCT05038839	Phase I	Cabozantinib + Pamiparib	Cabozantinib and Pamiparib for the Treatment of Advanced of Refractory Solid Tumors	Active, not recruiting	USA	0
NCT04317105	Phase Ib/II	Copanlisib + Ipilimumab + Nivolumab Copanlisib + Nivolumab	Testing the Addition of an Anti-cancer Drug, Copanlisib, to the Usual Immunotherapy (Nivolumab With or Without Ipilimumab) in Patients With Advanced Solid Cancers That Have Changes in the Following Genes: PIK3CA and PTEN	Active, not recruiting	USA \| CAN	0
NCT05843253	Phase II	Everolimus + Ribociclib	Study of Ribociclib and Everolimus in HGG and DIPG	Recruiting	USA \| NLD \| GBR \| DEU \| CAN \| AUS	0
NCT02920450	Phase Ib/II	Carboplatin + Gedatolisib + Paclitaxel	Study of Paclitaxel, Carboplatin, and PF-05212384 in Advanced or Metastatic NSCLC (UF-STO-LUNG-002)	Terminated	USA	0
NCT02761694	Phase I	ARQ 751 + Paclitaxel ARQ 751 ARQ 751 + Fulvestrant	ARQ 751 as a Single Agent or in Combination With Other Anti-Cancer Agents, in Solid Tumors With PIK3CA / AKT / PTEN Mutations	Terminated	USA	0
NCT03317119	Phase I	Trametinib + Trifluridine-tipiracil hydrochloride	Trametinib and Trifluridine and Tipiracil Hydrochloride in Treating Patients With Colon or Rectal Cancer That is Advanced, Metastatic, or Cannot Be Removed by Surgery	Completed	USA	0
NCT04632992	Phase II	Ipatasertib Atezolizumab + Capecitabine Entrectinib Atezolizumab + Docetaxel Ado-trastuzumab emtansine + Atezolizumab Capecitabine + Pertuzumab/trastuzumab/hyaluronidase-zzxf Paclitaxel + Pertuzumab/trastuzumab/hyaluronidase-zzxf Alectinib Inavolisib Pertuzumab/trastuzumab/hyaluronidase-zzxf Docetaxel + Pertuzumab/trastuzumab/hyaluronidase-zzxf Atezolizumab + Paclitaxel Ado-trastuzumab emtansine + Tucatinib	A Study Evaluating Targeted Therapies in Participants Who Have Advanced Solid Tumors With Genomic Alterations or Protein Expression Patterns Predictive of Response (MyTACTIC)	Completed	USA	0
NCT01884285	Phase I	AZD8186 Abiraterone + AZD8186 AZD8186 + Vistusertib	AZD8186 First Time In Patient Ascending Dose Study	Completed	USA \| GBR \| ESP \| CAN	0
NCT02189174	Phase Ib/II	CLR457	Study of CLR457 Administered Orally in Adult Patients With Advanced Solid Malignancies	Terminated	USA \| ESP \| CAN	2
NCT01097278	Phase 0	Cholecalciferol	S0812 High Dose Cholecalciferol in Premenopausal Women at High-Risk for Breast Cancer	Completed	USA	0
NCT03218826	Phase I	AZD8186 + Docetaxel	PI3Kbeta Inhibitor AZD8186 and Docetaxel in Treating Patients Advanced Solid Tumors With PTEN or PIK3CB Mutations That Are Metastatic or Cannot Be Removed by Surgery	Active, not recruiting	USA	0
NCT03209401	Phase I	Carboplatin + Niraparib	Niraparib Plus Carboplatin in Patients With Homologous Recombination Deficient Advanced Solid Tumor Malignancies	Terminated	USA	0
NCT04216472	Phase II	Alpelisib + Nab-paclitaxel	Nab-paclitaxel and Alpelisib for the Treatment of Anthracycline Refractory Triple Negative Breast Cancer With PIK3CA or PTEN Alterations	Active, not recruiting	USA	0
NCT04108858	Phase Ib/II	Copanlisib + Pertuzumab + Trastuzumab Pertuzumab + Trastuzumab	Testing the Addition of an Anti-cancer Drug, Copanlisib, to the Usual Maintenance Treatment (Trastuzumab and Pertuzumab) After Initial Chemotherapy in a Phase Ib/II Trial for Advanced HER2 Positive Breast Cancer	Terminated	USA	0
NCT05379972	Phase II	Olaparib + Pembrolizumab	Study of SBRT/Olaparib Followed by Pembrolizumab/Olaparib in Gastric Cancers	Recruiting	USA	0
NCT03842228	Phase I	Copanlisib + Durvalumab + Olaparib	Testing the Combination of the Anti-cancer Drugs Copanlisib, Olaparib, and MEDI4736 (Durvalumab) in Patients With Advanced Solid Tumors With Selected Mutations	Active, not recruiting	USA	0
NCT05082025	Phase II	Copanlisib + Fulvestrant	Phase 2 Study of PI3K Inhibitor Copanlisib in Combination With Fulvestrant in Selected ER+ and/or PR+ Cancers With PI3K (PIK3CA, PIK3R1) and/or PTEN Alterations	Active, not recruiting	USA	0
NCT04770246	Phase II	TAS-117	TAS-117 in Patients With Advanced Solid Tumors Harboring Germline PTEN Mutations	Terminated	USA \| GBR \| FRA \| AUT	0
NCT05010096	Phase I	Copanlisib + Elimusertib	BAY1895344 and Copanlisib for the Treatment of Molecularly Selected Patients With Advanced Solid Tumors	Withdrawn		0
NCT02401347	Phase II	Talazoparib	Phase II Trial of Talazoparib in BRCA1/2 Wild-type HER2-negative Breast Cancer and Other Solid Tumors	Completed	USA	0
NCT06029998	Phase II	Bortezomib	Bortezomib in Patients With Metastatic Castration-Resistant Prostate Cancer With PTEN Deletion (BORXPTEN)	Recruiting	USA	0
NCT06287463	Phase Ib/II	DCC-3084	Study of DCC-3084 in Participants With Advanced Malignancies Driven by the Mitogen-Activated Protein Kinase (MAPK) Pathway	Recruiting	USA	0
NCT03207529	Phase I	Alpelisib + Enzalutamide	Alpelisib and Enzalutamide in Treating Patients With Androgen Receptor and PTEN Positive Metastatic Breast Cancer	Completed	USA	0
NCT03065062	Phase I	Gedatolisib + Palbociclib	Study of the CDK4/6 Inhibitor Palbociclib (PD-0332991) in Combination With the PI3K/mTOR Inhibitor Gedatolisib (PF-05212384) for Patients With Advanced Squamous Cell Lung, Pancreatic, Head & Neck and Other Solid Tumors	Recruiting	USA	0
NCT05691465	Phase II	lutetium Lu 177 dotatate	Testing the Safety and Effectiveness of Radiation-based Treatment (Lutetium Lu 177 Dotatate) for Metastatic Prostate Cancer That Has Neuroendocrine Cells	Recruiting	USA	0
NCT00770263	Phase I	Erlotinib + Temsirolimus	Erlotinib and Temsirolimus for Solid Tumors	Completed	USA	0
NCT04737109	Phase Ib/II	Darolutamide + Ipatasertib	Neoadjuvant Androgen Deprivation, Darolutamide, and Ipatasertib in Men With Localized, High Risk Prostate Cancer	Terminated	USA	0
NCT05773326	Phase I	Temsirolimus	Superselective Intra-arterial Cerebral Infusion of Temsirolimus in HGG	Recruiting	USA	0
NCT03131908	Phase Ib/II	GSK2636771 + Pembrolizumab	Study of the Selective PI3K-Beta Inhibitor GSK2636771 in Combination With Pembrolizumab in Patients With Metastatic Melanoma and PTEN Loss	Active, not recruiting	USA	0
NCT01458067	Phase I	GSK2636771	A Phase I/IIa, First Time in Human, Study of GSK2636771 in Subjects With Advanced Solid Tumors With Phosphatase and Tensin Homolog (PTEN) Deficiency	Completed	USA \| GBR	1
NCT02576444	Phase II	Adavosertib + Olaparib Olaparib Capivasertib + Olaparib Ceralasertib + Olaparib	OLAParib COmbinations (OLAPCO)	Terminated	USA	0
NCT03673787	Phase Ib/II	Atezolizumab + Ipatasertib	A Trial of Ipatasertib in Combination With Atezolizumab (IceCAP)	Unknown status	GBR	0
NCT05810870	Phase II	Eribulin + MEN1611 MEN1611	PIK3CA/PTEN-altered Advanced Breast Cancer Treated With MEN1611 Monotherapy or in Combination With Eribulin (SABINA)	Recruiting	ESP	0
NCT04586270	Phase I	TAS0612	A Study of TAS0612 in Participants With Advanced or Metastatic Solid Tumor Cancer	Recruiting	USA \| FRA	0
NCT02987959	Phase II	Sapanisertib	Study of TAK-228 (MLN0128) in Soft Tissue Sarcomas	Terminated	USA	0
NCT03834740	Phase I	Everolimus + Ribociclib	A Phase 0 /II Study of Ribociclib (LEE011) in Combination With Everolimus in Preoperative Recurrent High-Grade Glioma Patients Scheduled for Resection	Completed	USA	0
NCT06218667	Phase Ib/II	Copanlisib + Degarelix	A Study of Copanlisib in Combination With Degarelix in People With Prostate Cancer	Withdrawn		0
NCT04251533	Phase III	Alpelisib + Nab-paclitaxel Nab-paclitaxel	Study Assessing the Efficacy and Safety of Alpelisib + Nab-paclitaxel in Subjects With Advanced TNBC Who Carry Either a PIK3CA Mutation or Have PTEN Loss (EPIK-B3)	Active, not recruiting	USA \| TUR \| SVN \| SVK \| POL \| NOR \| ITA \| ISR \| HUN \| HRV \| GBR \| FRA \| ESP \| DEU \| CHE \| BRA \| BGR \| AUT \| AUS \| ARG	10
NCT02215096	Phase I	Enzalutamide GSK2636771	Dose-finding Study of GSK2636771 When Administered in Combination With Enzalutamide in Male Subjects With Metastatic Castration-Resistant Prostate Cancer	Completed	USA \| GBR	0
NCT03624543	Phase II	CFI-400945	CFI-400945 in Patients With Advanced/Metastatic Breast Cancer	Active, not recruiting	CAN	0
NCT04388852	Phase I	DS-3201b + Ipilimumab	DS3201 and Ipilimumab for the Treatment of Metastatic Prostate, Urothelial and Renal Cell Cancers	Recruiting	USA	0
NCT04551521	Phase II	Atezolizumab Atezolizumab + Ipatasertib Atezolizumab + Pertuzumab + Trastuzumab Atezolizumab + Cobimetinib Alectinib Atezolizumab + Cobimetinib + Vemurafenib	CRAFT: The NCT-PMO-1602 Phase II Trial	Recruiting	DEU	0
NCT02961283	Phase I	ASN003	Study of ASN003 in Subjects With Advanced Solid Tumors	Terminated	USA	0
NCT02549989	Phase II	LY3023414	Study of LY3023414 for the Treatment of Recurrent or Persistent Endometrial Cancer	Completed	USA	0
NCT05300048	Phase I	Serabelisib Nab-paclitaxel + Serabelisib	Combination of Serabelisib and Insulin Suppressing Diet With or Without Nab-paclitaxel in Subjects With Advanced Solid Tumors With PIK3CA Mutations	Active, not recruiting	USA	0
NCT02523014	Phase II	Abemaciclib GSK2256098 Vismodegib Capivasertib	Vismodegib, FAK Inhibitor GSK2256098, Capivasertib, and Abemaciclib in Treating Patients With Progressive Meningiomas	Recruiting	USA	0
NCT01396408	Phase II	Temsirolimus Sunitinib	A Phase II Study of Sunitinib or Temsirolimus in Patients With Advanced Rare Tumours	Active, not recruiting	CAN	0
NCT04042831	Phase II	Olaparib	Olaparib in Treating Patients With Metastatic Biliary Tract Cancer With Aberrant DNA Repair Gene Mutations	Recruiting	USA	0
NCT05933395	Phase II	Abemaciclib + Fulvestrant Fulvestrant + Neratinib Alpelisib + Fulvestrant Everolimus + Fulvestrant	Genetically-informed Therapy for ER+ Breast Cancer Post-CDK4/6 Inhibitor (GERTRUDE)	Recruiting	USA	0
NCT01306045	Phase II	Erlotinib Lapatinib MK2206 Sunitinib Selumetinib	Molecular Profiling and Targeted Therapy for Advanced Non-Small Cell Lung Cancer, Small Cell Lung Cancer, and Thymic Malignancies	Completed	USA	0
NCT01971515	Phase I	M2698	First-in-Human Dose Escalation Trial in Subjects With Advanced Malignancies	Completed	USA	0
NCT03297606	Phase II	Bosutinib Palbociclib Vismodegib Ipilimumab + Nivolumab Cobimetinib + Vemurafenib Temsirolimus Olaparib Erlotinib Crizotinib Sunitinib Afatinib Dasatinib Pertuzumab + Trastuzumab Axitinib	Canadian Profiling and Targeted Agent Utilization Trial (CAPTUR) (CAPTUR)	Recruiting	CAN	0
NCT02644122	Phase II	SF1126	SF1126 in Recurrent or Progressive SCCHN and Mutations in PIK3CA Gene and/or PI-3 Kinase Pathway Genes	Terminated	USA	0
NCT02315625	Phase II	Everolimus Sunitinib	Study of Mutation-Targeted Therapy With Sunitinib or Everolimus in People With Advanced Low- or Intermediate-Grade Neuroendocrine Tumors of the Gastrointestinal Tract and Pancreas With or Without Cytoreductive Surgery	Terminated	USA	0
NCT01470209	Phase I	Buparlisib + Everolimus	A Phase I Study of BKM120 and Everolimus in Advanced Solid Malignancies	Completed	USA	0
NCT04958226	Phase I	Capivasertib + Midazolam	A Study to Assess the Effect of Capivasertib on Midazolam in Patients With Advanced Solid Tumours	Completed	USA	0
NCT05768139	Phase Ib/II	Fulvestrant + STX-478 STX-478	First-in-Human Study of STX-478 as Monotherapy and in Combination With Other Antineoplastic Agents in Participants With Advanced Solid Tumors	Recruiting	USA \| ITA \| FRA \| ESP	0
NCT03337724	Phase II	Ipatasertib + Paclitaxel Paclitaxel	A Study of Ipatasertib in Combination With Paclitaxel as a Treatment for Participants With PIK3CA/AKT1/PTEN-Altered, Locally Advanced or Metastatic, Triple-Negative Breast Cancer or Hormone Receptor-Positive, HER2-Negative Breast Cancer (IPATunity130)	Completed	USA \| TUR \| SVN \| POL \| ITA \| HUN \| GRC \| GBR \| FRA \| ESP \| DEU \| CZE \| CAN \| BRA \| BEL \| AUS \| ARG	13
NCT04774952	Phase I	RMC-5552	Dose Escalation of RMC-5552 Monotherapy in Relapsed/Refractory Solid Tumors	Active, not recruiting	USA	0
NCT01226316	Phase I	Capivasertib	Safety, Tolerability & Potential Anti-cancer Activity of Increasing Doses of AZD5363 in Different Treatment Schedules	Active, not recruiting	USA \| NLD \| ITA \| GBR \| FRA \| ESP \| DNK \| CAN	2
NCT03207347	Phase II	Niraparib	A Trial of Niraparib in BAP1 and Other DNA Damage Response (DDR) Deficient Neoplasms (UF-STO-ETI-001)	Completed	USA	0
NCT03088059	Phase II	Niraparib Durvalumab + Monalizumab Methotrexate Carboplatin Rogaratinib Mitomycin C Docetaxel Afatinib Paclitaxel Durvalumab Monalizumab Palbociclib Bleomycin Gemcitabine Fluorouracil	Biomarker-based Study in R/M SCCHN (UPSTREAM)	Active, not recruiting	ITA \| GBR \| FRA \| ESP \| BEL	0
NCT03360721	Phase II	Abiraterone + Apalutamide + Prednisone	Apalutamide, Abiraterone Acetate, and Prednisone in Treating Participants With Metastatic Castration Resistant Prostate Cancer	Active, not recruiting	USA	0

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